What is special about the M3i Zero is that it comes with a USB adapter cable to hook up to your computer directly. While you will still use the included stylish Micro SD reader to add files onto the micro SD, the USB connection cable allows the M3i's hardware to be completely updated by new kernel firmware from the M3i team. This insures future compatibility with any update Nintendo might release.
Along with that crucial firmware flashing ability the M3i Zero also features its own custom GUI interface with built in media player. It's really easy to use and doesn't rely on separate Moonshell homebrew like you would be forced to use with other cards like the DSTT and R4i SDHC. Faster loading, tighter integration, and the support of the best team in the business; things you won't find with lesser R4i SDHC cards. Even if you're still plodding along with a DS Lite and a DSTT ds flash card, the M3i Zero is fully backwards compatible with older DS systems.
Refer: http://www.ideamarketers.com/?r4i_sdhc&articleid=896259